Which of the following is a sign that the IV line may be occluded?

Inability to infuse fluid is a key sign that the IV line may be occluded. When an IV line is functioning properly, fluids should be able to flow freely through the line into the patient's bloodstream. If there is an obstruction or blockage in the IV line, either at the insertion site or further along in the tubing, the nurse will experience difficulty in infusing fluids. This can be due to a variety of reasons, including kinks in the tubing, a clot at the catheter tip, or even a poorly positioned catheter.

Other indicators can serve as additional context for assessing IV line patency, but the inability to infuse fluid is a direct indication of a problem with the flow caused by obstruction. It prompts immediate evaluation and intervention to maintain effective IV therapy.