Which symptom is NOT typically associated with a systemic reaction to IV therapy?

Bruising at the injection site is not typically associated with a systemic reaction to IV therapy. Systemic reactions often arise from the body's overall response to an allergen or irritant entering the bloodstream, leading to widespread effects. Symptoms such as difficulty breathing, rash, and fever indicate the body's systemic response, which could be due to an allergic reaction, anaphylaxis, or infection.

Bruising, on the other hand, is localized and usually results from trauma to blood vessels during the insertion of an IV. It does not reflect a systemic response affecting the entire body or indicate an immune response. Therefore, while bruising can occur as a result of IV therapy, it is not a symptom associated with systemic reactions.